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Invitrogen
Cytokeratin 10/14/15/16/19 Recombinant Rabbit Monoclonal Antibody (7M6B0)
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Cytokeratin 10/14/15/16/19 Antibody (MA569782) in IHC (P)
Immunohistochemistry analysis of Cytokeratin 10/14/15/16/19 on paraffin-embedded Human esophagus tissue. Samples were incubated with Cytokeratin 10/14/15/16/19 recombinant monoclonal antibody (Product # MA569782) using a dilution of 1:200 (40x lens). Followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) using a dilution of 1:500 (Red). DAPI was used for nuclear staining (Blue). High pressure ... View More
产品信息
MA569782
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7M6B0
抗原
Synthetic peptide.
偶联物
形式
Liquid
浓度
1.42 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3., with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 40-kDa keratin intermediate filament; 56 kDa cytokeratin; Acidic Cytokeratin; Cell proliferation-inducing gene 46 protein; CK-10; CK-14; CK-15; CK-16; CK-18; CK-19; CK-9; cytokeratin 10; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 9; Cytokeratin endo B; Cytokeratin-10; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-18; Cytokeratin-19; Cytokeratin-9; Endo B; epidermal keratin 10; epidermolysis bullosa simplex, Dowling-Meara, Koebner; focal non-epidermolytic palmoplantar keratoderma; HMWCK; intermediate filament protein; intermediate filament protein K16; K10; K14; K15; K16; K18; K19; K9; keratin 10, type I; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 15, type I; keratin 16 homolog; keratin 16, type I; keratin 18, type I; keratin 19, type I; keratin 9 (epidermolytic palmoplantar keratoderma); keratin 9, type I; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 1, acidic, gene 9; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; Keratin, type I cytoskeletal 9; keratin, type I, 40-kd; Keratin-10; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-18; Keratin-19; Keratin-9; krt10 {ECO:0000250|UniProtKB:P13645}; krt15 {ECO:0000250|UniProtKB:P19012}; krt18 {ECO:0000250|UniProtKB:P05783}; krt9; ORF; pan keratin; pankeratin; PIG46; Spermatid perinuclear ring manchette protein K9; suprabasal cytokeratin 10; type I cytokeratin; type I cytoskeletal 15; type I cytoskeletal 9; Type I keratin Ka10; Type I keratin Ka14; Type I keratin Ka15; type I keratin KA16; Type I keratin Ka19; unnamed protein product
基因别名: AI324768; AI528832; AI626930; AI663979; BCIE; BIE; CK-18; CK-9; CK10; CK14; CK15; CK16; CK18; CK19; CYK18; D130054E02Rik; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS3; EBS4; EHK; EHK2; EHK2A; EHK2B; EndoC; EPPK; EPPK1; FNEPPK; IHL; K10; K14; K15; K16; K18; K19; K1C1; K1CO; K1CP; K1CS; K9; Ka10; Ka14; Ka15; Ka16; Ka19; Kerd; KPP; Krt-1.10; Krt-1.14; Krt-1.19; Krt1-10; Krt1-14; Krt1-15; Krt1-16; Krt1-18; Krt1-19; Krt1-9; KRT10; KRT14; KRT15; KRT16; KRT16A; KRT18; KRT19; KRT9; KRTB; NEPPK; NFJ; PC1; PIG46
UniProt ID: (Human) P13645, (Human) P02533, (Human) P19012, (Human) P08779, (Human) P05783, (Human) P08727, (Human) P35527, (Mouse) P02535, (Rat) Q6IFW6, (Mouse) Q61781, (Rat) Q6IFV1, (Mouse) Q61414, (Rat) Q6IFV3, (Mouse) Q9Z2K1, (Rat) Q5BJY9, (Mouse) P05784, (Mouse) P19001, (Rat) Q63279, (Rat) Q8CIS9, (Mouse) Q6RHW0
Entrez Gene ID: (Human) 3858, (Human) 3861, (Human) 3866, (Human) 3868, (Human) 3875, (Human) 3880, (Human) 3857, (Mouse) 16661, (Rat) 450225, (Mouse) 16664, (Rat) 287701, (Mouse) 16665, (Rat) 287700, (Mouse) 16666, (Rat) 303530, (Rat) 294853, (Mouse) 16668, (Mouse) 16669, (Rat) 360626, (Rat) 266717, (Mouse) 107656
structural molecule activity
protein binding
structural constituent of epidermis
protein heterodimerization activity
structural constituent of cytoskeleton
keratin filament binding
scaffold protein binding
RNA binding
cadherin binding involved in cell-cell adhesion
structural constituent of muscle
macromolecular complex binding
molecular_function
poly(A) RNA binding
protein complex binding
morphogenesis of an epithelium
immune system process
inflammatory response
aging
keratinocyte differentiation
negative regulation of cell migration
keratinization
hair cycle
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
mitophagy in response to mitochondrial depolarization
epidermis development
response to radiation
intermediate filament organization
intermediate filament bundle assembly
stem cell differentiation
epithelial cell differentiation
Notch signaling pathway
response to estrogen
sarcomere organization
cell differentiation involved in embryonic placenta development
cellular response to calcium ion
biological_process
response to zinc ion
response to ionizing radiation
anatomical structure morphogenesis
tumor necrosis factor-mediated signaling pathway
Golgi to plasma membrane protein transport
negative regulation of apoptotic process
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
cell-cell adhesion
intermediate filament-based process
spermatogenesis
skin development
cytoskeleton organization
peptide cross-linking
positive regulation of epidermis development
protein heterotetramerization
Golgi to plasma membrane CFTR protein transport
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