Invitrogen

Cytokeratin 14/17 Polyclonal Antibody

Name: Cytokeratin 14\/17 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-68451

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

Cytokeratin 14/17 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 2

Cytokeratin 14/17 Antibody (PA5-68451) in IHC (P)

Immunohistochemical analysis of Cytokeratin 14/17 in paraffin embedded human skin tissue using Cytokeratin 14/17 Polyclonal Antibody (Product # PA5-68451) at a 1:200 dilution.

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Immunogen image

Immunogen Image Cytokeratin 14/17 Polyclonal Antibody

产品信息

PA5-68451

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:10,000

免疫组化（石蜡） (IHC (P))

1:100-1:300

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human Cytokeratin 14/17 [aa 261-310].

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2688416

产品详细信息

Predicted to react with Mouse and Rat samples.

靶标信息

Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 39.1; CK-14; CK-17; cytokeratin 14; Cytokeratin-14; Cytokeratin-17; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; K17; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 17, type I; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 17; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 17; Keratin-14; Keratin-17; krt17 {ECO:0000250|UniProtKB:Q04695}; Type I keratin Ka14; Type I keratin Ka17

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基因别名: 39.1; AI626930; CK-17; CK14; EBS3; EBS4; K14; K17; Ka14; Ka17; Krt-1.14; Krt1-14; Krt1-17; KRT14; KRT17; NFJ; PC; PC2; PCHC1