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Invitrogen
Cytokeratin 14 Recombinant Rabbit Monoclonal Antibody (RM328)
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产品信息
MA5-33037
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM328
抗原
A peptide corresponding to C-terminus of human Cytokeratin-14.
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: reacts to human Cytokeratin-14. It may also react to mouse or rat Cytokeratin-14, as predicted by immunogen homology.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CK-14; cytokeratin 14; Cytokeratin-14; K14; keratin 14, type I; Keratin, type I cytoskeletal 14; Keratin-14; Koebner
基因别名: CK14; EBS3; EBS4; K14; KRT14; NFJ
UniProt ID: (Human) P02533
Entrez Gene ID: (Human) 3861
