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产品信息
180267
产品规格
种属反应
Human
宿主/亚型
Mouse
分类
Monoclonal
类型
Antibody
克隆号
D5/16B4
抗原
Purified Cytokeratin 5 and 6
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
purified
保存液
PBS with 1% BSA
内含物
0.1% sodium azide
保存条件
2-8°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2925245
产品详细信息
This monoclonal antibody reacts with Cytokeratin 5/6, and reacts weakly with Cytokeratin 4. It stains the basal cells of squamous and glandular epithelia, part of stratum spinosum of squamous epithelium, myoepithelium, and mesothelium. It does not stain adenous epithelium. Therefore, this antibody can be used to distinguish squamous carcinoma from adenocarcinoma, and to differentiate epitheloid mesothelioma from non-epitheliod mesothelioma and adenocarcinoma. It is also a useful antibody to distinguish benign ductal hyperplasias from non-invasive neoplastic proliferations. Positive tissue: Skin.
Expected Staining Pattern: Cytoplasmic
靶标信息
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 58 kDa cytokeratin; CK-5; CK-6A; CK-6B; CK-6D; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; K6A; K6B; kamp-keratin derived antimicrobial peptide; KDAMP; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin 6B, type II; keratin K6h; keratin, epidermal type II, K6A; keratin, epidermal, type II, K6B; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; Keratin-5; Keratin-6A; Keratin-6B; keratin-6C; keratin-like 1 (a type II keratin sequence); Type-II keratin Kb10; type-II keratin Kb12; Type-II keratin Kb5; Type-II keratin Kb6
基因别名: CK-6B; CK-6C; CK-6E; CK5; CK6A; CK6B; CK6C; CK6D; DDD; DDD1; EBS2; K5; K6A; K6B; K6C; K6D; KRT5; KRT5A; KRT6A; KRT6B; KRT6C; KRT6D; KRTL1; PC2; PC3; PC4
UniProt ID: (Human) P13647, (Human) P02538, (Human) P04259
Entrez Gene ID: (Human) 3852, (Human) 3853, (Human) 3854
