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NeoBiotechnologies
Cytokeratin, Basic (Type II or HMW) Recombinant Mouse Monoclonal Antibody (rKRTH, 2148)
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产品信息
MSM32-2148-P1
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
rKRTH, 2148
抗原
Solubilized keratin extract from human stratum corneum
偶联物
形式
Liquid
浓度
200 µg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; CK 2e; CK-1; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-72; CK-8; cytokeratin 1; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin-1; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6D; Cytokeratin-7; Cytokeratin-72; Cytokeratin-8; Cytoskeletal 57 kDa keratin; cytoskeletal protein; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; Epithelial keratin-2e; Hair alpha protein; intermediate filament protein; K7; K1; K2e; K2P; K3; K4; K5; K6A; K7; K72; K76; K8; keratin 1, type II; keratin 2 epidermis; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6, inner root sheath, 2; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 72, pseudogene; keratin 72, type II; keratin 76, type II; keratin 8, type II; keratin 86; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 35; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; keratin K5; keratin protein K6irs; keratin type II; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 72; Keratin, type II cytoskeletal 8; Keratin-1; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; Keratin-7; Keratin-72; Keratin-76; Keratin-8; krt1 {ECO:0000250|UniProtKB:P04264}; krt2; krt2 {ECO:0000250|UniProtKB:P35908}; krt4 {ECO:0000250|UniProtKB:P19013}; KRT5; krt7; krt7 {ECO:0000250|UniProtKB:P08729}; krt76; MGC116967; MGC116968; mK6-alpha; pan keratin; Sarcolectin; tuftelin interacting protein 8; Type II inner root sheath-specific keratin-K6irs2; type II intermediate filament protein; type II keratin Kb1; type II keratin Kb2; type II keratin Kb35; type II keratin Kb4; type II keratin Kb7; type II keratin Kb9; type II keratin subunit protein; type II mesothelial keratin K7; Type-II keratin Kb1; Type-II keratin Kb2; Type-II keratin Kb3; Type-II keratin Kb35; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9; type-II keratin-35; unnamed protein product
基因别名: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; AA960620; AEI2; AI507495; AL022697; AU019895; AW108092; AW146334; BB005427; CARD2; CK-2e; CK-4; CK-6C; CK-6E; CK-72; CK-8; CK1; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK4; CYK8; CYKER; D15Wsu77e; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EHK; EHK1; EndoA; EPPK; HUMCYT2A; K1; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K6irs; K6IRS2; K7; K72; K8; Kb1; Kb2; KB35; Kb4; Kb7; Kb9; Ker2; KO; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; KRT1A; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-35; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; Krt2-8; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; KRT6; KRT6A; KRT6C; KRT6D; KRT6IRS2; KRT7; KRT72; Krt72-ps; KRT76; KRT8; Krt86; KRTA; KRTE; MECD2; mK6[a]; MK6a; NEPPK; PC3; Sak57; SCL; Tfip8; WSN1
UniProt ID: (Human) P04264, (Human) P35908, (Human) P12035, (Human) P19013, (Human) P13647, (Human) P02538, (Human) P08729, (Human) Q14CN4, (Human) Q01546, (Human) P05787, (Mouse) P04104, (Rat) Q6IMF3, (Rat) Q6IG02, (Mouse) Q3TTY5, (Mouse) P07744, (Rat) Q6IG00, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Mouse) Q9DCV7, (Rat) Q6IG12, (Mouse) Q6IME9, (Rat) Q6IG04, (Mouse) Q3UV17, (Rat) Q10758, (Mouse) P11679
Entrez Gene ID: (Human) 3848, (Human) 3849, (Human) 3850, (Human) 3851, (Human) 3852, (Human) 3853, (Human) 3855, (Human) 140807, (Human) 51350, (Human) 3856, (Mouse) 16678, (Rat) 300250, (Rat) 406228, (Mouse) 16681, (Mouse) 16682, (Rat) 315323, (Rat) 369017, (Mouse) 110308, (Mouse) 16687, (Mouse) 110310, (Rat) 300242, (Mouse) 105866, (Rat) 406227, (Rat) 407757, (Mouse) 77055, (Rat) 25626, (Mouse) 16691
protein binding
carbohydrate binding
structural constituent of epidermis
signaling receptor activity
protein heterodimerization activity
structural constituent of cytoskeleton
cytoskeletal protein binding
scaffold protein binding
structural molecule activity
molecular_function
protein complex binding
intermediate filament-based process
keratinization
intermediate filament organization
cytoskeleton organization
embryo development
epithelial cell differentiation
negative regulation of epithelial cell proliferation
complement activation, lectin pathway
negative regulation of inflammatory response
establishment of skin barrier
retina homeostasis
biological_process
epidermis development
sebaceous gland development
hair follicle morphogenesis
keratinocyte activation
keratinocyte proliferation
keratinocyte migration
tumor necrosis factor-mediated signaling pathway
sarcomere organization
response to hydrostatic pressure
response to other organism
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
morphogenesis of an epithelium
positive regulation of cell proliferation
cell differentiation
killing of cells of other organism
wound healing
defense response to Gram-positive bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of entry of bacterium into host cell
cell morphogenesis involved in differentiation
multicellular organism development
Wnt signaling pathway
response to mechanical stimulus
regulation of cell migration
regulation of protein localization
intermediate filament polymerization
pigmentation
response to oxidative stress
peptide cross-linking
fibrinolysis
regulation of angiogenesis
protein heterotetramerization
keratinocyte development
positive regulation of epidermis development
intermediate filament cytoskeleton organization
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