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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Cytokeratin Pan Type I/II Antibodies

          Invitrogen

          Cytokeratin Pan Type I/II Recombinant Rabbit Monoclonal Antibody (HL2253)

          查看其他51个Cytokeratin Pan Type I/II抗体

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          Cite Cytokeratin Pan Type I/II Recombinant Rabbit Monoclonal Antibody (HL2253)

          • 抗体检测数据 (3)
          Cytokeratin Pan Type I/II Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Cytokeratin Pan Type I/II Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 3

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          Cytokeratin Pan Type I/II Antibody (MA5-56831) in IHC (P)

          Immunohistochemistry (Paraffin) analysis of Cytokeratin Pan Type I/II stained by Cytokeratin Pan Type I/II Recombinant Monoclonal Antibody (Product # MA5-56831). Cytokeratin Pan Type I/II antibody detects pan Cytokeratin protein at cell membrane and cytoplasm on Paraffin-embedded mouse skin diluted at 1:51. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          Cytokeratin Pan Type I/II Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Cytokeratin Pan Type I/II Antibody in Western Blot (WB)
          Cytokeratin Pan Type I/II Antibody in Western Blot (WB)
          Cytokeratin Pan Type I/II Recombinant Rabbit Monoclonal Antibody (HL2253)

          产品信息

          MA5-56831

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1000-1:10000
          -

          免疫组化(石蜡) (IHC (P))

          1:51-1:1000
          -
          产品规格

          种属反应

          Human, Mouse

          宿主/亚型

          Rabbit / IgG

          Expression System

          HEK293 cells

          分类

          Recombinant Monoclonal

          类型

          Antibody

          克隆号

          HL2253

          抗原

          Recombinant fragmemt of human Cytokeratin.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Protein A

          保存液

          PBS

          内含物

          no preservative

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Dry ice (international)

          RRID

          AB_3679857

          靶标信息

          Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          引用该产品

          生物信息学

          蛋白别名: 39.1; 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; Cell proliferation-inducing gene 46 protein; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin endo B; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; Cytokeratin-7; Cytokeratin-8; Cytoskeletal 57 kDa keratin; embryonic type II keratin 1; Embryonic type II keratin-1; Endo B; epidermal keratin 10; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis 1; Epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; Hair alpha protein; HMWCK; intermediate filament protein; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K2P; K3; K4; K5; K6A; K7; K76; K77; K8; kamp-keratin derived antimicrobial peptide; KDAMP; keratin 1, type II; keratin 10, type I; keratin 13, type I; keratin 14, type I; keratin 15, type I; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19, type I; Keratin 1B; keratin 2 epidermis; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8, type II; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin K6h; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; keratin, type I, 40-kd; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; keratin-6C; Keratin-7; Keratin-76; Keratin-77; Keratin-8; KRT1B; krt2; krt5; krt7; krt76; mK6-alpha; Pan CK; pan Cytokeratin; pan keratin; pankeratin; Sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type I cytoskeletal 15; type II cytoskeletal 1b; type II keratin Kb39; type II mesothelial keratin K7; type-II intermediate filament protein; Type-II keratin Kb1; type-II keratin Kb12; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9

          查看更多 收起

          基因别名: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 39.1; 4732484G22Rik; AA960620; AI324768; AI528832; AI626930; AI663979; AL022697; AU019895; AW108092; AW146334; BB005427; BCIE; BIE; CARD2; CK-17; CK-18; CK-2e; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK18; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; D130054E02Rik; D15Wsu77e; DDD; DDD1; EBS2; EBS3; EBS4; EHK; EHK1; EndoA; EndoC; EPPK; FNEPPK; HUMCYT2A; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1C1; K1CO; K1CP; K1CS; K1emb; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K7; K8; Ker2; Kerd; KO; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1A; KRT1B; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; Krt2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; Krt6; KRT6A; KRT6C; KRT6D; KRT7; KRT76; KRT77; KRT8; Krt86; KRTA; KRTB; KRTE; mK1b; mK6[a]; MK6a; NEPPK; NFJ; PC; PC1; PC2; PC3; PCHC1; PIG46; SCL; Tfip8; WSN1; WSN2

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          UniProt ID: (Human) P86104, (Human) P13645, (Human) P13646, (Human) P02533, (Human) P19012, (Human) P08779, (Human) Q04695, (Human) P05783, (Human) P08727, (Human) P35908, (Human) P12035, (Human) P19013, (Human) P13647, (Human) P02538, (Human) P08729, (Human) Q01546, (Human) Q7Z794, (Human) P05787, (Mouse) P04104, (Mouse) P02535, (Mouse) Q6PAI1, (Mouse) Q61781, (Mouse) Q61414, (Mouse) Q9Z2K1, (Mouse) Q9QWL7, (Mouse) P05784, (Mouse) P19001, (Mouse) Q3TTY5, (Mouse) P07744, (Mouse) Q922U2, (Mouse) P50446, (Mouse) Q9DCV7, (Mouse) Q3UV17, (Mouse) Q6IFZ6, (Mouse) P11679

          查看更多 收起

          Entrez Gene ID: (Human) 3848, (Human) 3858, (Human) 3860, (Human) 3861, (Human) 3866, (Human) 3868, (Human) 3872, (Human) 3875, (Human) 3880, (Human) 3849, (Human) 3850, (Human) 3851, (Human) 3852, (Human) 3853, (Human) 3855, (Human) 51350, (Human) 374454, (Human) 3856, (Mouse) 16678, (Mouse) 16661, (Mouse) 16663, (Mouse) 16664, (Mouse) 16665, (Mouse) 16666, (Mouse) 16667, (Mouse) 16668, (Mouse) 16669, (Mouse) 16681, (Mouse) 16682, (Mouse) 110308, (Mouse) 16687, (Mouse) 110310, (Mouse) 77055, (Mouse) 406220, (Mouse) 16691

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          功能
          receptor activity structural molecule activity protein binding carbohydrate binding structural constituent of epidermis structural constituent of cytoskeleton keratin filament binding scaffold protein binding MHC class II receptor activity MHC class II protein binding poly(A) RNA binding cadherin binding involved in cell-cell adhesion structural constituent of muscle protein complex binding molecular_function protein heterodimerization activity
          参与通路
          epithelial cell differentiation intermediate filament cytoskeleton organization morphogenesis of an epithelium signal transduction positive regulation of cell growth hair follicle morphogenesis keratinization intermediate filament organization positive regulation of translation positive regulation of hair follicle development complement activation, lectin pathway retina homeostasis response to oxidative stress fibrinolysis regulation of angiogenesis negative regulation of inflammatory response establishment of skin barrier mitophagy in response to mitochondrial depolarization cytoskeleton organization cellular response to calcium ion cell cycle anatomical structure morphogenesis viral process tumor necrosis factor-mediated signaling pathway Golgi to plasma membrane CFTR protein transport negative regulation of apoptotic process extrinsic apoptotic signaling pathway hepatocyte apoptotic process cell-cell adhesion biological_process embryo development negative regulation of epithelial cell proliferation epidermis development sebaceous gland development aging response to zinc ion response to ionizing radiation hemidesmosome assembly hair cycle intermediate filament bundle assembly immune system process inflammatory response keratinocyte differentiation negative regulation of cell migration innate immune response keratinocyte migration Notch signaling pathway response to estrogen sarcomere organization cell differentiation involved in embryonic placenta development keratinocyte activation keratinocyte proliferation cell morphogenesis involved in differentiation multicellular organism development response to hydrostatic pressure response to other organism Wnt signaling pathway wound healing cell proliferation response to radiation tongue morphogenesis cellular response to retinoic acid
          It has to be done as per old AB suggested Products section.
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