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Invitrogen
Cytomegalovirus UL147 Polyclonal Antibody
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产品信息
PA5-149128
产品规格
种属反应
Virus
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant viral CMV UL147/vCXC2
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Cytomegalovirus (CMV) UL147 is a gene encoded by the human cytomegalovirus (HCMV), a member of the herpesvirus family known for its ability to establish lifelong latent infections in the host. The UL147 gene encodes a protein that is part of the UL146-UL147 gene cluster, which is believed to play a role in modulating the host immune response. UL147 is thought to encode a chemokine-like protein that can interact with host chemokine receptors, potentially influencing the migration and activation of immune cells. This interaction can help the virus evade the host immune system, promoting viral persistence and contributing to the pathogenesis of HCMV. HCMV infection can lead to significant health issues, particularly in immunocompromised individuals and newborns, causing diseases such as retinitis, pneumonia, and congenital CMV infection. Understanding the function and mechanisms of UL147 is crucial for developing antiviral therapies and vaccines aimed at controlling HCMV infections. Research into UL147 and its role in immune modulation provides valuable insights into the complex interactions between HCMV and the host immune system.
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