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Alomone Labs, LTD
D4 Dopamine Receptor Polyclonal Antibody
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D4 Dopamine Receptor Antibody (ADR-004-200UL) in WB
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: - 1,2. Anti-D4Dopamine Receptor Antibody (#ADR-004), (1:200).3,4. Anti-D4Dopamine Receptor Antibody , preincubated with D4 Dopamine Receptor Blocking Peptide (#BLP-DR004).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
ADR-004-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RRWEAARHTKLHSR, corresponding to amino acid residues 215-228 of rat DRD4, 3rd intracellular loop
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
规格
160 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: d(2C) dopamine receptor; Dopamine 4 receptor; dopamine D4 receptor; dopamine receptor 4; unnamed protein product
基因别名: D4R; D4RA; Drd-4
UniProt ID: (Mouse) P51436
Entrez Gene ID: (Rat) 25432, (Mouse) 13491
dopamine neurotransmitter receptor activity, coupled via Gi/Go
G-protein coupled receptor activity
adrenergic receptor activity
dopamine neurotransmitter receptor activity
G-protein coupled serotonin receptor activity
protein binding
SH3 domain binding
neurotransmitter receptor activity
dopamine binding
identical protein binding
epinephrine binding
norepinephrine binding
heterocyclic compound binding
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
dopamine receptor signaling pathway
chemical synaptic transmission
short-term memory
circadian rhythm
associative learning
adult locomotory behavior
olfactory learning
response to light stimulus
photoperiodism
negative regulation of synaptic transmission, GABAergic
response to histamine
locomotory exploration behavior
regulation of locomotion
regulation of dopamine metabolic process
fear response
regulation of circadian rhythm
positive regulation of MAPK cascade
response to ethanol
regulation of neurotransmitter secretion
behavioral response to cocaine
response to steroid hormone
arachidonic acid secretion
negative regulation of protein secretion
negative regulation of synaptic transmission
regulation of calcium-mediated signaling
regulation of transport
retina development in camera-type eye
inhibitory postsynaptic potential
prepulse inhibition
phospholipase C-activating dopamine receptor signaling pathway
positive regulation of penile erection
response to epinephrine
adrenergic receptor signaling pathway
response to thyroid hormone
G protein-coupled serotonin receptor signaling pathway
modulation of inhibitory postsynaptic potential
regulation of postsynaptic membrane neurotransmitter receptor levels
regulation of postsynaptic neurotransmitter receptor internalization
presynaptic modulation of chemical synaptic transmission
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
positive regulation of excitatory postsynaptic potential
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adult behavior
response to cocaine
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