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Alomone Labs, LTD
D4 Dopamine Receptor Polyclonal Antibody
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D4 Dopamine Receptor Antibody (ADR-004-200UL) in WB
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: - 1,2. Anti-D4Dopamine Receptor Antibody (#ADR-004), (1:200).3,4. Anti-D4Dopamine Receptor Antibody , preincubated with D4 Dopamine Receptor Blocking Peptide (#BLP-DR004).
产品信息
ADR-004-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RRWEAARHTKLHSR, corresponding to amino acid residues 215-228 of rat DRD4, 3rd intracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4
基因别名: AW125663; D4R; D4RA; Drd-4; Drd4
UniProt ID: (Mouse) P51436
Entrez Gene ID: (Rat) 25432, (Mouse) 13491
dopamine neurotransmitter receptor activity, coupled via Gi/Go
dopamine neurotransmitter receptor activity
protein binding
drug binding
SH3 domain binding
dopamine binding
identical protein binding
signal transducer activity
G-protein coupled receptor activity
G-protein coupled amine receptor activity
G-protein coupled receptor
activation of MAPK activity
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
dopamine receptor signaling pathway
short-term memory
circadian rhythm
locomotory behavior
associative learning
adult locomotory behavior
olfactory learning
photoperiodism
negative regulation of cAMP biosynthetic process
positive regulation of sodium:proton antiporter activity
positive regulation of kinase activity
response to histamine
regulation of dopamine metabolic process
fear response
regulation of circadian rhythm
regulation of neurotransmitter secretion
behavioral response to cocaine
response to steroid hormone
arachidonic acid secretion
negative regulation of protein secretion
modulation of synaptic transmission
regulation of calcium-mediated signaling
retina development in camera-type eye
inhibitory postsynaptic potential
positive regulation of penile erection
negative regulation of voltage-gated calcium channel activity
positive regulation of excitatory postsynaptic potential
signal transduction
G-protein coupled receptor signaling pathway
chemical synaptic transmission
sensory perception of chemical stimulus
rhythmic process
