Invitrogen

D4 Dopamine Receptor Polyclonal Antibody

查看其他14个D4 Dopamine Receptor抗体

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
D4 Dopamine Receptor Polyclonal Antibody

产品信息

PA5-72569

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:10-1:50
-

流式细胞分析 (Flow)

1:10-1:50
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 365-391 amino acids from the Central region of human DRD4
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2718423

靶标信息

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4; seven transmembrane helix receptor

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基因别名: AW125663; D4DR; D4R; Drd-4; DRD4

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UniProt ID: (Human) P21917, (Mouse) P51436

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Entrez Gene ID: (Human) 1815, (Mouse) 13491

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功能
dopamine neurotransmitter receptor activity, coupled via Gs dopamine neurotransmitter receptor activity, coupled via Gi/Go dopamine neurotransmitter receptor activity protein binding drug binding potassium channel regulator activity SH3 domain binding dopamine binding identical protein binding signal transducer activity G-protein coupled receptor activity G-protein coupled amine receptor activity G-protein coupled receptor
参与通路
activation of MAPK activity behavioral fear response synaptic transmission, dopaminergic response to amphetamine cellular calcium ion homeostasis negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway dopamine receptor signaling pathway short-term memory circadian rhythm adult locomotory behavior olfactory learning photoperiodism negative regulation of cAMP biosynthetic process positive regulation of sodium:proton antiporter activity positive regulation of kinase activity response to histamine social behavior regulation of dopamine metabolic process dopamine metabolic process fear response regulation of circadian rhythm regulation of neurotransmitter secretion behavioral response to cocaine behavioral response to ethanol response to steroid hormone arachidonic acid secretion negative regulation of protein secretion regulation of calcium-mediated signaling positive regulation of dopamine uptake involved in synaptic transmission retina development in camera-type eye inhibitory postsynaptic potential positive regulation of penile erection negative regulation of voltage-gated calcium channel activity positive regulation of excitatory postsynaptic potential signal transduction G-protein coupled receptor signaling pathway chemical synaptic transmission sensory perception of chemical stimulus associative learning rhythmic process modulation of synaptic transmission
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