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Alomone Labs, LTD
D5 Dopamine Receptor (extracellular) Polyclonal Antibody
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D5 Dopamine Receptor (extracellular) Antibody (ADR-005-200UL) in IHC (F)
Expression ofD5dopamine receptor in rat striatum - Immunohistochemical staining of perfusion-fixed rat brain frozen using Anti-D5Dopamine Receptor (extracellular) Antibody (#ADR-005), (1:100). A. DRD5 (green) appears in a subset of striatal neurons and in the striatal matrix. B. Staining of the same section with calbindin D28k (red), a marker of interneurons. C. Merging the two images demonstrates that DRD5... View More
产品信息
ADR-005-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EEGWELEGRTENC, corresponding to amino acid residues 199-211 of rat DRD5, 2nd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D(1B) dopamine receptor; D(5) dopamine receptor; D1b receptor; Dopamine 5 receptor; Dopamine D5 receptor; dopamine receptor 5; DRD 1B; DRD 5; Hd5dr; MGC10601
基因别名: D1B; D5R; Drd-5; Drd1b; Drd5; Gpcr1
UniProt ID: (Mouse) Q8BLD9, (Rat) P25115
Entrez Gene ID: (Mouse) 13492, (Rat) 25195
synaptic transmission, dopaminergic
response to amphetamine
regulation of systemic arterial blood pressure by vasopressin
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
negative regulation of protein kinase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
dopamine receptor signaling pathway
chemical synaptic transmission
mating behavior
associative learning
visual learning
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
transmission of nerve impulse
negative regulation of cell migration
positive regulation of cAMP biosynthetic process
negative regulation of NAD(P)H oxidase activity
wound healing
response to cocaine
positive regulation of adenylate cyclase activity
negative regulation of blood pressure
regulation of female receptivity
sensitization
regulation of long-term neuronal synaptic plasticity
long term synaptic depression
cellular response to catecholamine stimulus
reactive oxygen species metabolic process
