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Invitrogen
DAB2 Polyclonal Antibody
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Product Details
PA5-19615
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 750 to the C-terminus of Human DAB2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with zebrafish and orangutan based on sequence homology.
Target Information
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adaptor molecule disabled-2; Dab, mitogen-responsive phosphoprotein, homolog 2; DAB2, clathrin adaptor protein; Differentially expressed in ovarian carcinoma 2; Differentially-expressed protein 2; Disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein; DOC-2; FLJ26626; mitogen responsive phosphoprotein; unnamed protein product
Gene Aliases: DAB2; DOC-2; DOC2
UniProt ID: (Human) P98082
Entrez Gene ID: (Human) 1601
negative regulation of transcription from RNA polymerase II promoter
endocytosis
receptor-mediated endocytosis
apoptotic process
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
positive regulation of epithelial to mesenchymal transition
negative regulation of neuron projection development
protein transport
Wnt signaling pathway
cell differentiation
negative regulation of cell growth
positive regulation of cell migration
positive regulation of aldosterone biosynthetic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
leading edge cell differentiation
negative regulation of apoptotic process
positive regulation of endocytosis
positive regulation of transcription from RNA polymerase II promoter
clathrin coat assembly
response to steroid hormone
negative regulation of epithelial cell proliferation
positive regulation of SMAD protein import into nucleus
negative regulation of androgen receptor signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to epidermal growth factor stimulus
cellular response to transforming growth factor beta stimulus
negative regulation of canonical Wnt signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
response to salt
negative regulation of protein localization to plasma membrane
positive regulation of Wnt signaling pathway, planar cell polarity pathway
positive regulation of clathrin-mediated endocytosis
positive regulation of early endosome to late endosome transport
positive regulation of aldosterone secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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