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NeoBiotechnologies
DAXX (Transcriptional Corepressor) Monoclonal Antibody (PCRP-DAXX-5G11)
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产品信息
1616-MSM6-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
PCRP-DAXX-5G11
抗原
Recombinant full-length human DAXX protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CENP-C binding protein; DADB-159G18.9; Daxx; Death domain-associated protein 6; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126245; MGC126246; SMIM40
基因别名: BING2; DAP6; DAXX; EAP1
UniProt ID: (Human) Q9UER7
Entrez Gene ID: (Human) 1616
p53 binding
transcription corepressor activity
receptor signaling protein activity
protein binding
transcription factor binding
enzyme binding
protein kinase binding
protein kinase activator activity
heat shock protein binding
ubiquitin protein ligase binding
histone binding
protein N-terminus binding
androgen receptor binding
general transcription factor
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of JUN kinase activity
extrinsic apoptotic signaling pathway via death domain receptors
response to metal ion
negative regulation of myotube differentiation
viral process
covalent chromatin modification
androgen receptor signaling pathway
PML body organization
regulation of protein ubiquitination
positive regulation of histone phosphorylation
positive regulation of apoptotic process
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
cellular response to tumor necrosis factor
cellular response to anoxia
positive regulation of neuron death
