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Invitrogen
DAZAP1 Polyclonal Antibody
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产品信息
PA5-52074
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EPRDSKSQAP GQPGASQWGS RVVPNAANGW AGQPPPTWQQ GYGPQGMWVP AGQAIGGYGP PPAGRGAPPP PPPFTSYIVS TPPGGFPPPQ GFPQGYGAPP QFSFGYGPPP PPPDQFAPPG VPPPPA
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
靶标信息
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAZ-associated protein 1; Deleted in azoospermia-associated protein 1; MGC19907; testicular tissue protein Li 50
基因别名: 2410042M16Rik; DAZAP1; mPrrp
UniProt ID: (Human) Q96EP5, (Mouse) Q9JII5
Entrez Gene ID: (Human) 26528, (Mouse) 70248, (Rat) 362836
