Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: NECDVCTDQL FGAARPDDPT LISRNSRFSS WETVCDSLDD YNHLVTLCNG TYEGLLRRNQ MGRNSMKLPT LKDIRDCLSL QKFDNPPFFQ NSTFSFRNAL EGFDKADGTL DSQVMSLHNL VHSFLNGTNA LPHSAANDPI FVVLHSFTDA
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 52%.
The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DCT; dopachrome delta-isomerase; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); DT; L-dopachrome Delta-isomerase; L-dopachrome isomerase; L-dopachrome tautomerase; TRP-2; TRP2; tyrosinase related protein-2; Tyrosinase-related protein 2; tyrosine-related protein 2
基因别名: DCT; TRP-2; TYRP2
UniProt ID: (Human) P40126
Entrez Gene ID: (Human) 1638
分子生物学功能: oxygenase