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Abnova
DDIT3 Monoclonal Antibody (2G3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00001649-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2G3
抗原
DDIT3 (AAH03637, 1 a.a. approximately 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL
靶标信息
GADD153 is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP GADD153 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of GADD153 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alternative DDIT3 protein; C/EBP zeta; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; growth arrest and DNA damage-inducible protein GADD153; MGC4154; unnamed protein product
基因别名: AltDDIT3; C/EBPzeta; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153
UniProt ID: (Human) P35638
Entrez Gene ID: (Human) 1649
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
cAMP response element binding protein binding
identical protein binding
protein homodimerization activity
leucine zipper domain binding
protein heterodimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
transcription regulator inhibitor activity
transcription regulator activator activity
negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
response to wounding
anterior/posterior axis specification
gene expression
regulation of autophagy
endoplasmic reticulum unfolded protein response
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
negative regulation of interleukin-4 production
positive regulation of interleukin-8 production
response to endoplasmic reticulum stress
intracellular signal transduction
response to platelet-derived growth factor
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of neuron apoptotic process
cell redox homeostasis
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
artery development
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein localization to mitochondrion
negative regulation of canonical Wnt signaling pathway
negative regulation of cold-induced thermogenesis
integrated stress response signaling
HRI-mediated signaling
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
vascular associated smooth muscle cell migration
intrinsic apoptotic signaling pathway in response to nitrosative stress
vascular associated smooth muscle cell proliferation
negative regulation of determination of dorsal identity
positive regulation of intrinsic apoptotic signaling pathway
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