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Invitrogen
DDR2 Recombinant Rabbit Monoclonal Antibody (102)
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产品信息
MA5-31105
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
102
抗原
Recombinant Mouse DDR2/CD167b Protein (Met1-Arg399)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse DDR2/CD167b.
靶标信息
DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD167 antigen-like family member B; CD167b; CD_antigen: CD167b; Discoidin domain receptor 2; Discoidin domain-containing receptor 2; hydroxyaryl-protein; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; RP11-572K18.1; Tyrosine-protein kinase TYRO10
基因别名: AW495251; Ddr2; Ntrkr3; Tkt; Tyro10
UniProt ID: (Mouse) Q62371
Entrez Gene ID: (Mouse) 18214
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
collagen binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein tyrosine kinase collagen receptor activity
transmembrane signal receptor
ossification
endochondral bone growth
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
positive regulation of fibroblast migration
phosphorylation
peptidyl-tyrosine phosphorylation
collagen fibril organization
regulation of bone mineralization
biomineral tissue development
chondrocyte proliferation
collagen-activated tyrosine kinase receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of protein kinase activity
protein autophosphorylation
positive regulation of fibroblast proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of extracellular matrix disassembly
