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Invitrogen
DDR2 Monoclonal Antibody (3B11E4)
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产品信息
MA5-15356
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
3B11E4
抗原
Purified recombinant fragment of human DDR2 expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-15356 targets DDR2 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15356 immunogen is purified recombinant fragment of human DDR2 expressed in E. Coli.
靶标信息
DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD167 antigen-like family member B; CD167b; CD_antigen: CD167b; cell migration-inducing protein 20; Discoidin domain receptor 2; discoidin domain receptor family, member 2; Discoidin domain-containing receptor 2; Discoidin domain-containing receptor tyrosine kinase 2; hydroxyaryl-protein; hydroxyaryl-protein kinase; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; RP11-572K18.1; Tyrosine-protein kinase TYRO10; tyrosylprotein kinase
基因别名: DDR2; MIG20a; NTRKR3; TKT; TYRO10
UniProt ID: (Human) Q16832
Entrez Gene ID: (Human) 4921
ossification
endochondral bone growth
cell adhesion
signal transduction
regulation of extracellular matrix disassembly
positive regulation of fibroblast migration
peptidyl-tyrosine phosphorylation
extracellular matrix organization
collagen fibril organization
regulation of bone mineralization
biomineral tissue development
chondrocyte proliferation
collagen-activated tyrosine kinase receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of protein kinase activity
protein autophosphorylation
positive regulation of fibroblast proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of extracellular matrix disassembly
