Invitrogen

DDX3 Monoclonal Antibody (3B9E3)

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说明书
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说明书
实验方案
问题与答案
技术支持
DDX3 Monoclonal Antibody (3B9E3)

产品信息

MA5-38509

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:200-1:1,000
-

免疫细胞化学 (ICC/IF)

1:200-1:1,000
-

流式细胞分析 (Flow)

1:200-1:400
-

酶联免疫吸附实验 (ELISA)

1:10,000
-
产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

3B9E3

抗原

Purified recombinant fragment of human DDX3X (aa: 518-661) expressed in E. Coli.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2898422

产品详细信息

This antibody has been tested in indirect ELISA.

靶标信息

The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ATP-dependent RNA helicase DDX3X; CAP-Rf; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3; D1Pas1-related sequence 2; DBX; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3; DEAD box protein 3, X-chromosomal; DEAD box RNA helicase DEAD3; DEAD box, X isoform; DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; DEAD/H box-3; Embryonic RNA helicase; fibroblast growth factor inducible 14; Helicase-like protein 2; HLP2; mDEAD3

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基因别名: CAP-Rf; D1Pas1-rs2; DBX; DDX14; DDX3; DDX3X; Dead3; Erh; Fin14; HLP2; MRX102

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UniProt ID: (Human) O00571, (Mouse) Q62167

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Entrez Gene ID: (Human) 1654, (Rat) 317335, (Mouse) 13205

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功能
DNA binding RNA binding GTPase activity ATP-dependent DNA helicase activity ATP-dependent RNA helicase activity protein binding ATP binding transcription factor binding poly(A) binding eukaryotic initiation factor 4E binding ATPase activity nucleoside-triphosphatase activity translation initiation factor binding RNA stem-loop binding ribosomal small subunit binding CTPase activity poly(A) RNA binding mRNA 5'-UTR binding cadherin binding involved in cell-cell adhesion nucleotide binding nucleic acid binding helicase activity hydrolase activity
参与通路
transcription, DNA-templated chromosome segregation extrinsic apoptotic signaling pathway via death domain receptors response to virus RNA secondary structure unwinding positive regulation of gene expression Wnt signaling pathway negative regulation of translation positive regulation of cell growth negative regulation of cell growth negative regulation of protein complex assembly DNA duplex unwinding positive regulation of interferon-beta production stress granule assembly intracellular signal transduction mature ribosome assembly positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of viral genome replication innate immune response positive regulation of translation positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation cellular response to arsenic-containing substance cellular response to osmotic stress positive regulation of chemokine (C-C motif) ligand 5 production intrinsic apoptotic signaling pathway cell-cell adhesion positive regulation of G1/S transition of mitotic cell cycle protein localization to cytoplasmic stress granule negative regulation of intrinsic apoptotic signaling pathway immune system process regulation of transcription, DNA-templated translational initiation regulation of translation apoptotic process regulation of gene expression ribosome biogenesis
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