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Invitrogen

DDX3/DDX3Y Recombinant Rabbit Monoclonal Antibody (1N2I8)

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产品信息

MA569170

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:100,000-1:120,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-

免疫沉淀 (IP)

0.5-4 µg
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

1N2I8

抗原

Recombinant protein (or fragment).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.11 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3., with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

DDX3 (DEAD-box helicase 3) is an RNA helicase involved in multiple cellular processes, including RNA splicing, transport, translation, and degradation. It has key roles in antiviral responses, cell cycle regulation, and apoptosis. DDX3 is involved in the regulation of gene expression at multiple levels and is critical in processes such as cell cycle regulation, apoptosis, and innate immune response to viral infections. DDX3 has been shown to interact with various cellular proteins and RNA molecules, influencing their stability and function. DDX3Y, also known as DBY, belongs to the DEAD-box protein family and is located on the Y chromosome at Yq11.It shares significant sequence and functional similarity with DDX3 but has a more restricted expression pattern, predominantly in the testes. Mutations or deletions in DDX3Y can lead to male infertility due to impaired spermatogenesis. The protein encoded by DDX3Y consists of conserved motifs for ATP binding and hydrolysis necessary for RNA unwinding, making it vital for the proper translation and stability of mRNAs during spermatogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ATP-dependent RNA helicase DDX3X; ATP-dependent RNA helicase DDX3Y; CAP-Rf; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3; D1Pas1 related sequence 1; D1Pas1-related sequence 1; D1Pas1-related sequence 2; DBX; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide, Y chromosome; DEAD box protein 3, X-chromosomal; DEAD box protein 3, Y-chromosomal; DEAD box RNA helicase DEAD3; DEAD box, X isoform; DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2); DEAD-box RNA helicase DEAD2; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome; DEAD/H box-3; Embryonic RNA helicase; fibroblast growth factor inducible 14; Helicase-like protein 2; HLP2; mDEAD2; mDEAD3; uncharacterized protein LOC364073; unnamed protein product

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基因别名: 8030469F12Rik; CAP-Rf; D1Pas1-rs1; D1Pas1-rs2; DBX; DBY; DDX14; DDX3; DDX3X; DDX3Y; Dead2; Dead3; Erh; Fin14; HLP2; MRX102; MRXSSB; RGD1309586

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UniProt ID: (Human) O00571, (Human) O15523, (Mouse) Q62167, (Mouse) Q62095

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Entrez Gene ID: (Human) 1654, (Human) 8653, (Rat) 317335, (Mouse) 13205, (Rat) 364073, (Mouse) 26900

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功能
nucleotide binding nucleic acid binding DNA binding DNA helicase activity RNA binding RNA helicase activity mRNA binding GTPase activity helicase activity protein binding ATP binding transcription factor binding poly(A) binding eukaryotic initiation factor 4E binding hydrolase activity ATPase activity nucleoside-triphosphatase activity translation initiation factor binding RNA strand annealing activity signaling adaptor activity RNA stem-loop binding gamma-tubulin binding ribosomal small subunit binding CTPase activity protein serine/threonine kinase activator activity cadherin binding mRNA 5'-UTR binding ATP-dependent DNA helicase activity ATP-dependent RNA helicase activity poly(A) RNA binding
参与通路
chromosome segregation metabolic process extrinsic apoptotic signaling pathway via death domain receptors response to virus RNA secondary structure unwinding positive regulation of gene expression negative regulation of translation positive regulation of cell growth negative regulation of cell growth negative regulation of protein complex assembly DNA duplex unwinding stress granule assembly intracellular signal transduction mature ribosome assembly positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of viral genome replication innate immune response positive regulation of translation positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation cellular response to arsenic-containing substance cellular response to osmotic stress intrinsic apoptotic signaling pathway positive regulation of G1/S transition of mitotic cell cycle negative regulation of intrinsic apoptotic signaling pathway immune system process cytoplasmic pattern recognition receptor signaling pathway translational initiation regulation of translation apoptotic process gamete generation negative regulation of gene expression Wnt signaling pathway cell differentiation positive regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 8 signaling pathway positive regulation of translation in response to endoplasmic reticulum stress ribosome biogenesis lipid homeostasis positive regulation of mitochondrial translation positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of canonical Wnt signaling pathway cellular response to virus positive regulation of NLRP3 inflammasome complex assembly negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein K63-linked ubiquitination protein localization to cytoplasmic stress granule transcription, DNA-templated regulation of transcription, DNA-templated regulation of gene expression
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