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Invitrogen
DDX5 Recombinant Rabbit Monoclonal Antibody (2C3)
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图: 1 / 4
DDX5 Antibody (MA5-49866) in ICC/IF
Immunocytochemistry analysis of HepG2 cells with DDX5 monoclonal antibody (Product # MA5-49866) at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-49866
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2C3
抗原
A synthesized peptide derived from human DDX5
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.4 mg/mL
规格
40 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 5; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5; DEAD box protein 5; DEAD box RNA helicase DEAD1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5; DKFZp434E109; DKFZp686J01190; mDEAD1; MGC118083; p68 RNA helicase; Probable ATP-dependent RNA helicase DDX5; RNA helicase p68; RP23-247J12.4
基因别名: 2600009A06Rik; DDX5; G17P1; HELR; HLR1; HUMP68; p68
Entrez Gene ID: (Mouse) 13207
nucleotide binding
nucleic acid binding
transcription cofactor activity
transcription coactivator activity
RNA binding
RNA helicase activity
ATP-dependent RNA helicase activity
helicase activity
protein binding
calmodulin binding
ATP binding
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
enzyme binding
estrogen receptor binding
pre-mRNA binding
poly(A) RNA binding
calcium-dependent protein binding
androgen receptor binding
negative regulation of transcription from RNA polymerase II promoter
regulation of alternative mRNA splicing, via spliceosome
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
mRNA processing
circadian rhythm
RNA splicing
mRNA transcription
RNA secondary structure unwinding
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of DNA damage response, signal transduction by p53 class mediator
regulation of viral genome replication
regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
regulation of androgen receptor signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
regulation of skeletal muscle cell differentiation
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