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Invitrogen
DEDD Polyclonal Antibody
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DEDD Antibody (PA5-78280) in ICC/IF
DEDD Polyclonal Antibody detects DEDD protein at nucleus by immunofluorescent analysis. Sample: NT2/D1 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: DEDD protein stained by DEDD Polyclonal Antibody (Product # PA5-78280) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
产品信息
PA5-78280
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human DEDD. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: mouse leukocyte treated with CFA
Predicted Reactivity: Rat (98%), Xenopus laevis (86%), Rhesus Monkey (99%), Bovine (97%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
DEDD encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Death effector domain-containing protein; Death effector domain-containing testicular molecule; DEDPro1; FLDED-1; tumor necrosis factor (ligand) superfamily, member 19
基因别名: CASP8IP1; DEDD; DEDD1; DEDPRO1; DEFT; FLDED1; KE05
UniProt ID: (Human) O75618, (Mouse) Q9Z1L3
Entrez Gene ID: (Human) 9191, (Mouse) 21945
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of protein catabolic process
regulation of apoptotic process
decidualization
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
spermatogenesis
