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Invitrogen
DENND1B Polyclonal Antibody
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产品信息
PA5-60036
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: AFLCGGSGDQ AEWNLGQDDS ALHGKHLPPS PRKRVSSSGL TDSLFILKEE NSNKHLGADN VSDPTSGLDF QLTSPEVSQT D
Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 67%.
靶标信息
Clathrin (see MIM 118955)-mediated endocytosis is a majormechanism for internalization of proteins and lipids. Members ofthe connecdenn family, such as DENND1B, function as guaninenucleotide exchange factors (GEFs) for the early endosomal smallGTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptorprotein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35activation with the clathrin machinery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Connecdenn 2; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; family with sequence similarity 31, member B; Protein FAM31B; RP11-53I24.2
基因别名: C1ORF18; C1orf218; DENND1B; FAM31B
UniProt ID: (Human) Q6P3S1
Entrez Gene ID: (Human) 163486
