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Invitrogen
DGKQ Monoclonal Antibody (652308)
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产品信息
MA5-61692
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
652308
抗原
E. coli-derived recombinant human DGK-theta , Asp696-Lys839
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-theta is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-theta co-localizes with phosphatidylinositol 4, 5-bisphosphate (PIP(2)). DGK-theta is the isoform responsive to alpha-Thrombin stimulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAG kinase theta; Dgk theta; DGK-theta; Diacylglycerol kinase theta; diacylglycerol kinase, delta (110 kDa); diacylglycerol kinase, theta 110kDa; Diglyceride kinase theta; testis tissue sperm-binding protein Li 38a
基因别名: 110kDa; DAGK; DAGK4; DAGK7; Dgkd; DGKQ
UniProt ID: (Human) P52824, (Rat) D3ZEY4, (Mouse) Q6P5E8
Entrez Gene ID: (Human) 1609, (Rat) 100361138, (Mouse) 110524
regulation of transcription from RNA polymerase II promoter
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
phosphorylation
cAMP-mediated signaling
platelet activation
response to ATP
thrombin receptor signaling pathway
protein kinase C signaling
signal transduction
intracellular signal transduction
