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Invitrogen
DHCR24 Recombinant Rabbit Monoclonal Antibody (HL3253)
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图: 1 / 3
DHCR24 Antibody (MA5-56870) in ICC/IF
Immunocytochemistry analysis of DHCR24 using DHCR24 Recombinant Monoclonal Antibody (Product # MA5-56870) in HepG2 cells fixed in ice-cold MeOH for 5 min. DHCR24 antibody diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody (Product # MA5-31466) Blue: Fluoroshield with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-56870
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL3253
抗原
Recombinant protein encompassing a sequence within the Intracellular domain of human Seladin 1. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol Delta-24-reductase; Delta(24)-sterol reductase; Diminuto/dwarf1 homolog; Seladin-1
基因别名: 2310076D10Rik; 5830417J06Rik; DHCR24; KIAA0018; mKIAA0018
UniProt ID: (Rat) Q5BQE6, (Mouse) Q8VCH6
Entrez Gene ID: (Rat) 298298, (Mouse) 74754
delta24(24-1) sterol reductase activity
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
enzyme binding
peptide antigen binding
delta24-sterol reductase activity
flavin adenine dinucleotide binding
catalytic activity
oxidoreductase activity, acting on CH-OH group of donors
reductase
cholesterol biosynthetic process
response to oxidative stress
Ras protein signal transduction
protein localization
steroid metabolic process
cholesterol metabolic process
negative regulation of cell proliferation
response to hormone
tissue development
sterol metabolic process
male genitalia development
plasminogen activation
amyloid precursor protein catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
skin development
oxidation-reduction process
membrane organization
lipid metabolic process
steroid biosynthetic process
sterol biosynthetic process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
