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Positive Control: U87-MG, SK-N-SH, IMR-32, SK-N-AS
Predicted reactivity: Human (98%), Mouse (89%), Rat (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bA555G22.1; DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog; Exosome complex exonuclease RRP44; exosome component 11; mitotic control protein dis3 homolog; Protein DIS3 homolog; Ribosomal RNA-processing protein 44; RP11-342J4.3
基因别名: 2810028N01Rik; DIS3; dis3p; EXOSC11; KIAA1008; RGD1304646; RRP44
UniProt ID: (Human) Q9Y2L1, (Mouse) Q9CSH3
Entrez Gene ID: (Human) 22894, (Mouse) 72662, (Rat) 306103
分子生物学功能: exoribonuclease