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DJ-1 Polyclonal Antibody

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DJ-1 Polyclonal Antibody

产品信息

PA5-120650

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human DJ-1/PARK7 (NP_009193.2).
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.63 mg/mL

规格

163 µg

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2914222

产品详细信息

Positive test controls include: HeLa, SH-SY5Y, BxPC-3, HepG2, Mouse thymus, Mouse kidney, Mouse pancreas, Rat brain, Rat testis. The target is usually found in the following locations: Cell membrane, Cytoplasm, Lipid-anchor, Membrane raft, Mitochondrion, Nucleus.

Immunogen sequence: MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTVAGLAG KDPVQCSRDV VICPDASLED AKKEGPYDVV VLPGGNLGAQ NLSESAAVKE ILKEQENRKG LIAAICAGPT ALLAHEIGFG SKVTTHPLAK DKMMNGGHYT YSENRVEKDG LILTSRGPGT SFEFALAIVE ALNGKEVAAQ VKAPLVLKD

靶标信息

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CAP1; contraception-associated protein 1; CTA-215D11.1; early onset 7; epididymis secretory sperm binding protein Li 67p; fertility protein SP22; FLJ27376; FLJ34360; FLJ92274; maillard deglycase; oncogene DJ1; oncogene Dj1; Parkinson disease protein 7; OTTHUMP00000001350; OTTHUMP00000001351; PARK7 GENE; PARK7/DJ1; Parkinson disease (autosomal recessive, early onset) 7; parkinson disease protein 7 homolog; parkinson protein 7; parkinsonism-associated deglycase; protein deglycase DJ-1; protein DJ-1; protein/nucleic acid deglycase DJ-1; RNA-binding protein regulatory subunit; unnamed protein product

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基因别名: CAP1; DJ-1; DJ1; GATD2; HEL-S-67p; SP22

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UniProt ID: (Human) Q99497, (Mouse) Q99LX0, (Rat) O88767

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Entrez Gene ID: (Human) 11315, (Mouse) 57320, (Rat) 117287

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功能
core promoter sequence-specific DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity mRNA binding receptor binding copper ion binding protein binding enzyme activator activity peptidase activity superoxide dismutase copper chaperone activity oxidoreductase activity, acting on peroxide as acceptor oxygen sensor activity enzyme binding kinase binding cytokine binding peptidase inhibitor activity receptor activator activity tyrosine 3-monooxygenase activator activity L-dopa decarboxylase activator activity protein deglycase activity identical protein binding protein homodimerization activity small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding cadherin binding mercury ion binding androgen receptor binding peroxiredoxin activity ubiquitin-protein transferase inhibitor activity scaffold protein binding DNA-binding transcription factor binding cupric ion binding cuprous ion binding ubiquitin-specific protease binding glyoxalase (glycolic acid-forming) activity RNA binding
参与通路
synaptic transmission, dopaminergic positive regulation of acute inflammatory response to antigenic stimulus DNA repair response to oxidative stress mitochondrion organization adult locomotory behavior methylglyoxal metabolic process detoxification of copper ion positive regulation of gene expression negative regulation of gene expression negative regulation of smooth muscle cell migration lactate biosynthetic process removal of superoxide radicals insulin secretion protein repair androgen receptor signaling pathway positive regulation of protein complex assembly negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-8 production negative regulation of protein sumoylation cellular response to stress positive regulation of NAD(P)H oxidase activity cellular response to oxidative stress cellular response to reactive oxygen species cellular response to glyoxal negative regulation of protein catabolic process response to hydrogen peroxide glucose homeostasis hydrogen peroxide metabolic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter glycolate biosynthetic process negative regulation of protein export from nucleus regulation of inflammatory response detoxification of mercury ion protein stabilization dopamine uptake involved in synaptic transmission regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling membrane depolarization membrane hyperpolarization regulation of androgen receptor signaling pathway detoxification of hydrogen peroxide cellular response to hydrogen peroxide detection of oxidative stress guanine deglycation guanine deglycation, glyoxal removal cellular detoxification of aldehyde cellular detoxification of methylglyoxal positive regulation of protein localization to nucleus regulation of synaptic vesicle endocytosis cellular response to oxygen-containing compound negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of death-inducing signaling complex assembly negative regulation of protein K48-linked deubiquitination negative regulation of TRAIL-activated apoptotic signaling pathway positive regulation of dopamine biosynthetic process glyoxal metabolic process glyoxal catabolic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of vascular smooth muscle cell proliferation negative regulation of NMDA glutamate receptor activity negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of fertilization positive regulation of oxidative phosphorylation uncoupler activity positive regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway spermatogenesis response to xenobiotic stimulus fertilization regulation of TRAIL production maternal process involved in female pregnancy cellular response to lipopolysaccharide cellular response to hypoxia Ras protein signal transduction response to testosterone regulation of fibril organization positive regulation of mitophagy
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