Invitrogen

DJ-1 Monoclonal Antibody (4B10)

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DJ-1 Monoclonal Antibody (4B10)

产品信息

MA5-49165

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.25-0.5 µg/mL
-

免疫组化（石蜡） (IHC (P))

2-5 µg/mL
-

免疫细胞化学 (ICC/IF)

5 µg/mL
-

流式细胞分析 (Flow)

1-3 µg/1x10^6 cells
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

4B10

抗原

E.coli-derived human PARK7 recombinant protein (Position: A2-D189).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3074823

产品详细信息

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Human PARK7 shares 91% amino acid (aa) sequence identity with both mouse and rat PARK7.

Positive Control - WB: human U20S whole cell, human HepG2 whole cell. IHC: human endometrial carcinoma tissue, human esophageal squamous carcinoma tissue, human liver cancer tissue. ICC/IF: Hela cell. Flow: Hela cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: CTA-215D11.1; DJ-1; early onset 7; epididymis secretory sperm binding protein Li 67p; FLJ27376; FLJ34360; FLJ92274; Maillard deglycase; Oncogene DJ1; OTTHUMP00000001350; OTTHUMP00000001351; PARK7 GENE; PARK7/DJ1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; parkinson protein 7; Parkinsonism-associated deglycase; Protein DJ-1; Protein/nucleic acid deglycase DJ-1

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基因别名: DJ-1; DJ1; HEL-S-67p; PARK7

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UniProt ID: (Human) Q99497

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Entrez Gene ID: (Human) 11315

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功能
core promoter binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity mRNA binding receptor binding copper ion binding protein binding transcription factor binding peptidase activity superoxide dismutase copper chaperone activity oxidoreductase activity, acting on peroxide as acceptor glyoxalase III activity enzyme binding kinase binding cytokine binding tyrosine 3-monooxygenase activator activity L-dopa decarboxylase activator activity identical protein binding protein homodimerization activity small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding mercury ion binding androgen receptor binding peroxiredoxin activity repressing transcription factor binding scaffold protein binding cadherin binding involved in cell-cell adhesion cupric ion binding cuprous ion binding ubiquitin-specific protease binding glyoxalase (glycolic acid-forming) activity
参与通路
negative regulation of protein phosphorylation negative regulation of protein kinase activity proteolysis protein deglycosylation autophagy inflammatory response mitochondrion organization Ras protein signal transduction single fertilization adult locomotory behavior detoxification of copper ion positive regulation of gene expression negative regulation of gene expression enzyme active site formation via L-cysteine sulfinic acid methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione lactate biosynthetic process protein repair negative regulation of protein ubiquitination negative regulation of protein binding activation of protein kinase B activity negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-8 production positive regulation of peptidyl-serine phosphorylation negative regulation of protein sumoylation cellular response to oxidative stress cellular response to glyoxal response to drug hydrogen peroxide metabolic process negative regulation of apoptotic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of TRAIL receptor biosynthetic process positive regulation of transcription from RNA polymerase II promoter glycolate biosynthetic process negative regulation of protein export from nucleus regulation of inflammatory response detoxification of mercury ion protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of ubiquitin-protein transferase activity dopamine uptake involved in synaptic transmission regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling membrane depolarization membrane hyperpolarization negative regulation of cell death regulation of androgen receptor signaling pathway cellular response to hydrogen peroxide positive regulation of protein homodimerization activity cell-cell adhesion cellular oxidant detoxification positive regulation of protein localization to nucleus negative regulation of neuron death positive regulation of superoxide dismutase activity negative regulation of protein acetylation positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of fibril organization positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of death-inducing signaling complex assembly negative regulation of protein K48-linked deubiquitination negative regulation of TRAIL-activated apoptotic signaling pathway positive regulation of pyrroline-5-carboxylate reductase activity positive regulation of tyrosine 3-monooxygenase activity positive regulation of dopamine biosynthetic process glyoxal catabolic process positive regulation of L-dopa biosynthetic process positive regulation of L-dopa decarboxylase activity negative regulation of oxidative stress-induced cell death negative regulation of hydrogen peroxide-induced cell death negative regulation of hydrogen peroxide-induced neuron death negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway positive regulation of reactive oxygen species biosynthetic process positive regulation of mitophagy negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway negative regulation of ubiquitin-specific protease activity positive regulation of oxidative phosphorylation uncoupler activity positive regulation of transcription regulatory region DNA binding positive regulation of androgen receptor activity negative regulation of extrinsic apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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