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Invitrogen
DLL3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-23448
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acid 100 to 150 of human DLL3.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Sequence homology: Cat (83%), Bovine (81%), Mouse, Rat (72%).
靶标信息
Delta-like protein 3 (DLL3) is a ligand for the Notch signaling pathway. It inhibits primary neurogenesis. DLL3 plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1). Mutations in DLL3 gene cause truncal shortening relative to their limbs, which leads to abdominal protrusion, abnormal spinal curvature and sometimes a plagiocephaly-torticollis sequence. It may be required to divert neurons along a specific differentiation pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: delta-like 3; delta3; drosophila Delta homolog 3; M-Delta-3; unnamed protein product
基因别名: pu; pudgy; SCDO1
UniProt ID: (Human) Q9NYJ7, (Mouse) O88516
Entrez Gene ID: (Human) 10683, (Mouse) 13389
skeletal system development
in utero embryonic development
cell fate determination
somitogenesis
Notch signaling pathway
compartment pattern specification
nervous system development
tissue development
negative regulation of Notch signaling pathway
paraxial mesoderm development
negative regulation of astrocyte differentiation
negative regulation of neurogenesis
positive regulation of neurogenesis
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