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Invitrogen
DLL4 Monoclonal Antibody (4A11)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-17068
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1/IgG2b
分类
Monoclonal
类型
Antibody
克隆号
4A11
抗原
Purified recombinant fragment of human DLL4 expressed in E. Coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-17068 targets DLL4 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. This product is derived from clone #4A11F8 Mouse IgG2b and clone #4A11G2 Mouse IgG1
The MA5-17068 immunogen is purified recombinant fragment of human DLL4 expressed in E. Coli.
MA5-17068 detects DLL4 which has a predicted molecular weight of approximately 74.6kDa.
靶标信息
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Delta-like protein 4; Delta4; Drosophila Delta homolog 4; MGC126344
基因别名: DLL4; UNQ1895/PRO4341
Entrez Gene ID: (Human) 54567
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