Invitrogen

DLL4 (delta-like 4) Monoclonal Antibody (HMD4-2), PE

Name: DLL4 (delta-like 4) Monoclonal Antibody (HMD4-2), PE
Brand: Invitrogen
SKU: MA5-28212

查看其他24个DLL4抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

MA5-28212

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Neat

产品规格

种属反应

Mouse

宿主/亚型

Hamster / IgG

分类

Monoclonal

类型

Antibody

克隆号

HMD4-2

抗原

Recombinant mouse DLL4

偶联物

PE PE PE

激发/发射光谱

565/576 nm 查看光谱

形式

Lyophilized

浓度

Conc. not determined

纯化类型

Protein G

保存液

PBS with 5% sucrose, 1% BSA

内含物

0.09% sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_2745183

产品详细信息

Reconstitute with 1.0 mL distilled water. Vial contains sample for 100 tests per 1 mL

Hamster anti Mouse Delta-Like Protein 4 antibody, clone HMD4-2 recognizes mouse Delta-like protein 4 (DLL4), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.

靶标信息

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.

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