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Invitrogen
DNA/Histone (H1) complex (Derlotuximab Biosimilar) Recombinant Human Monoclonal Antibody
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DNA/Histone (H1) complex (Derlotuximab Biosimilar) Antibody (MA5-41764) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human DNA/histone(H1) complex protein expressed in CHO cells using a DNA/Histone (H1) complex (Derlotuximab Biosimilar) monoclonal antibody (Product # MA5-41764). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-41764
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human DNA/histone(H1) complex
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
MA5-41764 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
靶标信息
The DNA-histone H1 complex consists of genomic DNA bound to histone H1, a linker histone that associates with the DNA between nucleosomes. Unlike core histones (H2A, H2B, H3, and H4), which form the nucleosome core particle, histone H1 binds to linker DNA at the entry and exit sites of the nucleosome, helping stabilize higher-order chromatin structure. This complex plays a key role in chromatin condensation, regulation of gene expression, and maintenance of genomic integrity. Under normal conditions, DNA-histone H1 complexes are confined to the nucleus. However, during cell death or tissue damage, these complexes can become extracellularly exposed, where they may contribute to immune activation or serve as tumor-associated targets in certain pathological settings.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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