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Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 1700030A21Rik; CSL-type zinc finger-containing protein 3; Diphthamide biosynthesis protein 4; DnaJ (Hsp40) homolog, subfamily C, member 24; DnaJ homolog subfamily C member 24; DPH4 homolog (JJJ3, S. cerevisiae); DPH4, JJJ3 homolog; zinc finger, CSL domain containing 3; zinc finger, CSL-type containing 3
基因别名: DNAJC24; DPH4; JJJ3; ZCSL3
UniProt ID: (Human) Q6P3W2
Entrez Gene ID: (Human) 120526