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Invitrogen
DNMT1 Polyclonal Antibody
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Product Details
PA5-120552
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 760-1109 of DNMT1 (NP_001370.1).
Conjugate
Form
Liquid
Concentration
2.23 mg/mL
Amount
223 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Jurkat. The target is usually found in the following locations: Nucleus.
Immunogen sequence: GDCVSVIPDD SSKPLYLARV TALWEDSSNG QMFHAHWFCA GTDTVLGATS DPLELFLVDE CEDMQLSYIH SKVKVIYKAP SENWAMEGGM DPESLLEGDD GKTYFYQLWY DQDYARFESP PKTQPTEDNK FKFCVSCARL AEMRQKEIPR VLEQLEDLDS RVLYYSATKN GILYRVGDGV YLPPEAFTFN IKLSSPVKRP RKEPVDEDLY PEHYRKYSDY IKGSNLDAPE PYRIGRIKEI FCPKKSNGRP NETDIKIRVN KFYRPENTHK STPASYHADI NLLYWSDEEA VVDFKAVQGR CTVEYGEDLP ECVQVYSMGG PNRFYFLEAY NAKSKSFEDP PNHARSPGNK
Target Information
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CXXC-type zinc finger protein 9; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase HsaI; DNA methyltransferase I; DNA methyltransferase MmuI; DNA MTase HsaI; DNA MTase MmuI; DNA MTase RnoIP; DNMT1; FLJ16293; m.RnoIP; MCMT; MGC104992; unnamed protein product
Gene Aliases: ADCADN; AIM; CXXC9; DNMT; DNMT1; Dnmt1o; HSN1E; m.HsaI; m.MmuI; MCMT; Met-1; Met1; MommeD2; MTase; Uim
UniProt ID: (Human) P26358, (Mouse) P13864
Entrez Gene ID: (Human) 1786, (Rat) 84350, (Mouse) 13433
DNA binding
chromatin binding
RNA binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
methyltransferase activity
zinc ion binding
methyl-CpG binding
DNA-methyltransferase activity
transferase activity
metal ion binding
lncRNA binding
promoter-specific chromatin binding
double-stranded DNA binding
transcription factor binding
S-adenosylmethionine-dependent methyltransferase activity
protein domain specific binding
estrogen receptor binding
histone deacetylase binding
unmethylated CpG binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
catalytic activity
DNA metabolism protein
DNA methyltransferase
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
methylation-dependent chromatin silencing
transcription, DNA-templated
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
methylation
regulation of cell proliferation
DNA methylation involved in embryo development
hypermethylation of CpG island
negative regulation of transcription, DNA-templated
cellular response to amino acid stimulus
chromosomal DNA methylation maintenance following DNA replication
cellular response to bisphenol A
positive regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell apoptotic process
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
DNA methylation
regulation of transcription, DNA-templated
brain development
aging
response to heat
response to toxic substance
response to organic substance
response to ionizing radiation
maintenance of DNA methylation
response to lead ion
DNA methylation on cytosine within a CG sequence
response to activity
gene silencing
chromatin modification
neuron differentiation
response to caffeine
response to nutrient levels
response to estradiol
response to lipopolysaccharide
DNA methylation on cytosine
response to vitamin A
response to testosterone
cellular response to platelet-derived growth factor stimulus
response to antidepressant
response to drug
DNA hypermethylation
response to ethanol
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
S-adenosylmethionine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to lead ion
cellular response to transforming growth factor beta stimulus
C-5 methylation of cytosine
cellular response to nerve growth factor stimulus
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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