Abnova

DOCK2 Monoclonal Antibody (2F4)

Name: DOCK2 Monoclonal Antibody (2F4)
Brand: Abnova
SKU: H00001794-M01

查看其他12个DOCK2抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

DOCK2 Antibody in Proximity Ligation Assay (PLA) (PLA)

图: 1 / 1

DOCK2 Antibody (H00001794-M01) in PLA

Proximity Ligation Analysis of protein-protein interactions between CD247 and DOCK2. HeLa cells were stained with anti-CD247 rabbit purified polyclonal 1:1200 and anti-DOCK2 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

Product Image Gallery

Immunogen image

Immunogen Image DOCK2 Monoclonal Antibody (2F4)

产品信息

H00001794-M01

应用

建议稀释比

已发表文章

酶联免疫吸附实验 (ELISA)

10 µg/mL

Proximity Ligation Assay (PLA) (PLA)

1:1200

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

2F4

抗原

DOCK2 (AAH16996, 1 a.a. approximately 336 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: MCVCAEDGKT LPVAVPIEDM QRIHLRFMFR HRSSLESKDK GEKNFAMSYV KLMKEDGTTL HDGFHDLVVL KGDSKKMEDA SAYLTLPSYR HHVENKGATL SRSSSSVGGL SVSSRDVFSI STLVCSTKLT QNVGLLGLLK WRMKPQLEES MRRLFESINN LMKSQYKTTI LLQVAALKYI PSVLHDVEMV FDAKLLSQLL YEFYTCIPPV KLQKQKVQSM NEIVQSNLFK KQECRDILLP VITKELKELL EQKDDMQHQV LERKYCVELL NSILEVLSYQ DAAFTYHHIQ EIMVQLLRTV NRTVITMGRD HILIGACCNC GFPSSTPHSL IQWLWG

靶标信息

Dedicator of cytokinesis 2 (DOCK2) is a gene located on chromosome 5q15, encoding a member of the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK2 plays a crucial role in the immune system by regulating the actin cytoskeleton, which is essential for cell movement and immune cell activation. It is predominantly expressed in hematopoietic cells, including lymphocytes and other leukocytes, where it facilitates chemotaxis and polarization by activating the small GTPase Rac. This activation is critical for processes such as lymphocyte homing, migration towards chemokines, and phagocytosis. Genetic mutations or dysregulation of DOCK2 can lead to immunodeficiency, characterized by impaired immune responses and increased susceptibility to infections. Research into DOCK2 focuses on its therapeutic potential in modulating immune responses and its role in disorders characterized by immune dysregulation, such as autoimmune diseases and chronic inflammation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。