Invitrogen

DOCK2 Monoclonal Antibody (OTI4E12)

Name: DOCK2 Monoclonal Antibody (OTI4E12)
Brand: Invitrogen
SKU: MA5-26548

查看其他12个DOCK2抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

DOCK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DOCK2 Antibody (MA5-26548) in IHC (P)

Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human ovary tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a DOCK2 monoclonal antibody (Product # MA5-26548).

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Immunogen Image DOCK2 Monoclonal Antibody (OTI4E12)

产品信息

MA5-26548

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:150

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

OTI4E12

抗原

Human recombinant protein fragment corresponding to amino acids 1544-1830 of DOCK2 produced in E.coli

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 1% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2723085

靶标信息

Dedicator of cytokinesis 2 (DOCK2) is a gene located on chromosome 5q15, encoding a member of the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK2 plays a crucial role in the immune system by regulating the actin cytoskeleton, which is essential for cell movement and immune cell activation. It is predominantly expressed in hematopoietic cells, including lymphocytes and other leukocytes, where it facilitates chemotaxis and polarization by activating the small GTPase Rac. This activation is critical for processes such as lymphocyte homing, migration towards chemokines, and phagocytosis. Genetic mutations or dysregulation of DOCK2 can lead to immunodeficiency, characterized by impaired immune responses and increased susceptibility to infections. Research into DOCK2 focuses on its therapeutic potential in modulating immune responses and its role in disorders characterized by immune dysregulation, such as autoimmune diseases and chronic inflammation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。