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Invitrogen
DOCK5 Polyclonal Antibody
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产品信息
PA5-66045
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: VELSVLFCKFI QSIPDNQLVR QKLNCMTKIV ESTLFRQSEC REVLLPLLTD QLSGQLDDNS NKPDHEASSQ LL
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 92%.
靶标信息
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dedicator of cytokinesis protein 5; FLJ21034
基因别名: DOCK5
UniProt ID: (Human) Q9H7D0
Entrez Gene ID: (Human) 80005
small GTPase mediated signal transduction
positive regulation of epithelial cell migration
positive regulation of GTPase activity
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of vascular smooth muscle contraction
positive regulation of vascular associated smooth muscle cell migration
