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Invitrogen
DPP4 Recombinant Rabbit Monoclonal Antibody (4C15)
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DPP4 Antibody (MA572329) in IHC (P)
Immunohistochemistry analysis of DPP4 on paraffin-embedded Human Duodenum tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Block endogenous peroxidase by 3% hydrogen peroxide for 20 min. Blocking buffer (normal goat serum) at 37°C for 30 min. Samples were incubated with DPP4 Recombinant Monoclonal (Product # MA572329) using a dilution at 1:100 overnight at 4°C. Followed by ... View More
产品信息
MA572329
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4C15
抗原
KLH conjugated synthetic peptide derived from human CD26.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD26 (dipeptidyl peptidase IV, DPP IV), adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. CD26 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. Further, CD26 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity. CD26 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADABP; ADCP-2; Adenosine deaminase complexing protein 2; Bile canaliculus domain-specific membrane glycoprotein; CD26; Dipeptidyl peptidase 4; Dipeptidyl peptidase IV; dipeptidylpeptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP IV; DPP-IV; Gly-Pro naphthylamidase; GP110 glycoprotein; Post-proline dipeptidyl aminopeptidase IV; T-cell activation antigen CD26; THAM; Thymocyte-activating molecule; TP103; Xaa-Pro-dipeptidylaminopeptidase
基因别名: ADABP; ADCP2; CD26; Dpp-4; DPP4; DPPIV; THAM; TP103
UniProt ID: (Human) P27487, (Mouse) P28843, (Rat) P14740
Entrez Gene ID: (Human) 1803, (Mouse) 13482, (Rat) 25253
virus receptor activity
protease binding
aminopeptidase activity
serine-type endopeptidase activity
receptor binding
protein binding
peptidase activity
serine-type peptidase activity
dipeptidyl-peptidase activity
hydrolase activity
identical protein binding
protein homodimerization activity
chemorepellent activity
collagen binding
peptide binding
serine protease
behavioral fear response
response to hypoxia
proteolysis
cell adhesion
positive regulation of cell proliferation
negative regulation of extracellular matrix disassembly
peptide hormone processing
receptor-mediated endocytosis of virus by host cell
T cell costimulation
regulation of cell-cell adhesion mediated by integrin
locomotory exploration behavior
psychomotor behavior
T cell activation
endothelial cell migration
viral entry into host cell
receptor-mediated virion attachment to host cell
negative chemotaxis
membrane fusion
negative regulation of neutrophil chemotaxis
glucagon processing
regulation of T cell mediated immunity
establishment of localization
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