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产品信息
PA5-19930
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide corresponding to amino acids 42 to 56 of human DR6 precursor.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ion-exchange chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152221
产品详细信息
In Western blot applications, this antibody detects a band at ~68kDa. A suggested positive control is Hela cell lysate.
PA5-19930 can be used with blocking peptide PEP-0055.
靶标信息
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD358; Death receptor 6; Death receptor-6; MGC31965; sCD358; sDR6; soluble CD358; soluble DR6; TNFR-related death receptor 6; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21
基因别名: BM-018; CD358; DR6; TNFRSF21; UNQ437/PRO868
UniProt ID: (Human) O75509
Entrez Gene ID: (Human) 27242
B cell apoptotic process
adaptive immune response
apoptotic process
inflammatory response
immune response
humoral immune response
negative regulation of B cell proliferation
negative regulation of myelination
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
negative regulation of T cell proliferation
myelination
regulation of apoptotic process
regulation of oligodendrocyte differentiation
T cell receptor signaling pathway
neuron apoptotic process
cellular response to tumor necrosis factor
apoptotic signaling pathway
oligodendrocyte apoptotic process
negative regulation of interleukin-5 secretion
negative regulation of interleukin-13 secretion
negative regulation of interleukin-10 secretion
