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Invitrogen
DRD1 Recombinant Rabbit Monoclonal Antibody (1H8L2)
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图: 1 / 5
DRD1 Antibody (702593) in ICC/IF
For immunocytochemistry analysis, HEK 293 cells stably transfected with Dopamine D1 receptor (D1R) were grown on poly-L-lysine-coated coverslips overnight. Cells were then treated with 10 µM dopamine for 30 min, washed with PBS and fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with Anti- DRD1 Recombinant Rabbit Monoclonal Antibody (Product # 702593, 1 µg/mL)... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
702593
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1H8L2
抗原
Peptide corresponding to human Dopamine Receptor D1 [aa427-aa446]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Cat, Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: D(1A) dopamine receptor; D1a receptor; Dopamine 1 receptor; Dopamine D1 receptor; dopamine receptor D1A; Dopamine-1A receptor
基因别名: D1a; Drd-1; DRD1; Drd1a
Entrez Gene ID: (Rat) 24316
dopamine neurotransmitter receptor activity, coupled via Gs
G-protein alpha-subunit binding
G-protein coupled receptor activity
dopamine neurotransmitter receptor activity
receptor binding
protein binding
drug binding
protein phosphatase binding
angiotensin receptor binding
D3 dopamine receptor binding
protein complex binding
dopamine binding
protein heterodimerization activity
ATPase binding
G-protein coupled receptor
temperature homeostasis
conditioned taste aversion
behavioral fear response
synaptic transmission, dopaminergic
startle response
response to amphetamine
negative regulation of protein kinase activity
protein import into nucleus
intracellular protein transport
muscle contraction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-activating dopamine receptor signaling pathway
dopamine receptor signaling pathway
chemical synaptic transmission
synapse assembly
learning
memory
mating behavior
grooming behavior
locomotory behavior
adult walking behavior
feeding behavior
associative learning
visual learning
response to organonitrogen compound
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
astrocyte development
response to organic cyclic compound
response to activity
dopamine transport
transmission of nerve impulse
neuronal action potential
regulation of vasoconstriction
calcium-mediated signaling
dentate gyrus development
striatum development
hippocampus development
orbitofrontal cortex development
cerebral cortex GABAergic interneuron migration
positive regulation of cell migration
negative regulation of cell migration
peristalsis
positive regulation of cAMP biosynthetic process
phosphatidylinositol catabolic process
response to food
response to estradiol
response to retinoic acid
cellular response to insulin stimulus
response to nicotine
operant conditioning
social behavior
response to antidepressant
regulation of dopamine metabolic process
response to cocaine
vasodilation
negative regulation of circadian sleep/wake cycle, sleep
response to drug
maternal behavior
response to amino acid
regulation of ion transport
response to morphine
response to ethanol
positive regulation of adenylate cyclase activity
positive regulation of membrane potential
glucose import
phosphatidylinositol metabolic process
habituation
sensitization
behavioral response to cocaine
regulation of long-term neuronal synaptic plasticity
response to steroid hormone
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of synaptic transmission, glutamatergic
prepulse inhibition
phospholipase C-activating dopamine receptor signaling pathway
long-term synaptic potentiation
long term synaptic depression
cellular response to hypoxia
cellular response to catecholamine stimulus
positive regulation of long-term synaptic potentiation
positive regulation of feeding behavior
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