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Invitrogen
DUSP12 Polyclonal Antibody
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产品信息
PA5-110753
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: YQAMGYEVDT SSAIYKQYRL QKVTEKYPEL QNLPQELFAV DPTTVSQGLK DEVLYKCRKC RRSLFRSSSI LDHREGSGPI AFAHKRMTPS SMLTTGRQAQ CTSYFIEPVQ WMESALLGVM DGQLLCPKCS AKLGSFNWYG EQCSCGRWI
Highest antigen sequence indentity to the following orthologs: Rat - 89%, Mouse - 89%.
靶标信息
Dual specificity phosphatase (DUSP) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs can be divided into six subgroups on the basis of sequence similarity (PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, atypical DUSPs). DUSP inhibitors might be used to manipulate MAPK and cellular responses in both positive and negative ways. The regulated expression and activity of DUSP family members in different cells and tissues controls MAPK intensity and duration to determine the type of physiological response. DUSP12 (YVH1, GKAP) contains the consensus DUSP catalytic domain as well as an extended C-terminal domain of unknown function, thought to be related to its potential role in glucokinase regulation. It is localized in the cytoplasm and nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase; YVH1 protein-tyrosine phosphatase ortholog
基因别名: DUSP1; DUSP12; YVH1
UniProt ID: (Human) Q9UNI6
Entrez Gene ID: (Human) 11266
