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Invitrogen
DYNC1H1 Polyclonal Antibody
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Product Details
PA5-51996
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DYNC1H1. Recombinant protein control fragment (Product #RP-89038).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSLETCMYDH KTFSEILNRV QKAVDDLNLH SYSNLPIWVN KLDMEIERIL GVRLQAGLRA WTQVLLGQAE DKAEVDMDTD APQVSHKPGG EPKIKNVVHE LRITNQVIYL NPPIEECRYK LYQEMFAWKM VVLSLPRIQS QR
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.
Target Information
DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1) is a gene that encodes a protein belonging to the dynein family, which are motor proteins critical for various cellular processes. Dyneins are responsible for retrograde intracellular transport along microtubules, meaning they move cargo from the periphery of the cell towards the nucleus. The DYNC1H1 protein is a heavy chain component of cytoplasmic dynein 1, which plays a key role in the movement of organelles, vesicles, and other cellular components. Mutations in DYNC1H1 have been associated with several neurological disorders, including spinal muscular atrophy with lower extremity predominance (SMA-LED) and Charcot-Marie-Tooth disease type 2O (CMT2O). Research into DYNC1H1 continues to uncover its involvement in cellular mechanics and its implications in various genetic conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic; dynein, cytoplasmic 1, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1
Gene Aliases: CMT2O; DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; DYNC1H1; HL-3; KIAA0325; p22; SMALED1
UniProt ID: (Human) Q14204
Entrez Gene ID: (Human) 1778
G2/M transition of mitotic cell cycle
ER to Golgi vesicle-mediated transport
microtubule-based movement
mitotic spindle organization
antigen processing and presentation of exogenous peptide antigen via MHC class II
cytoplasmic mRNA processing body assembly
stress granule assembly
establishment of spindle localization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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