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Invitrogen
DYRK2 Monoclonal Antibody (599542)
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DYRK2 Antibody (MA5-24269) in WB
Western blot analysis of DYRK2 in HepG2 human hepatocellular carcinoma cell line, CCD‚1070Sk human foreskin fibroblast cell line, and L6 rat myoblast cell line. Samples were incubated in DYRK2 monoclonal antibody (Product # MA5-24269) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Mouse IgG secondary antibody. A specific band was detected for DYRK2 at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
MA5-24269
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
C. elegans
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
599542
抗原
E. coli-derived recombinant human DYRK2 (aa 1-107)
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
DYRK2 (also known as dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2) belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development and is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 expressed in E. coli demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. DYRK2 also regulates p53 to induce apoptosis in response to DNA damage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
基因别名: DYRK2
UniProt ID: (Human) Q92630
Entrez Gene ID: (Human) 8445, (Rat) 314862
protein phosphorylation
cellular response to DNA damage stimulus
smoothened signaling pathway
peptidyl-tyrosine phosphorylation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of glycogen biosynthetic process
negative regulation of NFAT protein import into nucleus
regulation of signal transduction by p53 class mediator
