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Invitrogen
DYRK3 Polyclonal Antibody
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FIGURE: 1 / 2
DYRK3 Antibody (PA5-21875) in WB
Western Blot using DYRK3 Polyclonal Antibody (Product # PA5-21875). Various whole cell extracts (30 µg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with DYRK3 Polyclonal Antibody (Product # PA5-21875) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-21875
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Dyrk3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.68 mg/mL
Amount
68 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, H1299, HepG2, Raji, mouse liver.
Predicted reactivity: Mouse (92%), Rat (94%), Chimpanzee (99%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DYRK3 belongs to the DYRK family of dual-specificity protein kinases that catalyze phosphorylation of serine/threonine and tyrosine residues. The members of this family share structural similarity, but differ in their substrate specificity, suggesting their involvement in different cellular functions. DYRK3 is a negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3; Dual specificity tyrosine-phosphorylation-regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5; dyrk3; DYRK5; KSR; protein kinase Dyrk3; protein kinase; DYRK3; REDK; Regulatory erythroid kinase; RP11-343H5.2; RSU2; serine/threonine kinase; RED-L; serine/threonine kinase; RED-S; unnamed protein product
Gene Aliases: BC006704; DYRK3; DYRK5; hYAK3-2; RED; REDK
UniProt ID: (Human) O43781, (Mouse) Q8BM34
Entrez Gene ID: (Human) 8444, (Mouse) 226419
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
erythrocyte differentiation
nuclear speck organization
stress granule disassembly
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
cell division
regulation of cellular response to stress
positive regulation of cell cycle G2/M phase transition
organelle disassembly
regulation of TORC1 signaling
phosphorylation
peptidyl-tyrosine phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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