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Invitrogen
DcTRAILR1 Monoclonal Antibody (270012)
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DcTRAILR1 Antibody (MA5-23971) in ICC/IF
Immunocytochemistry analysis of DcTRAILR1 in immersion fixed mouse splenocytes. Samples were incubated in DcTRAILR1 monoclonal antibody (Product # MA5-23971) using a dilution of 10 µg/mL for 3 hours at room temperature. Cells were stained (red) and counterstained with DAPI (blue).
产品信息
MA5-23971
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
270012
抗原
Mouse myeloma cell line NS0-derived recombinant mouse DcTRAIL R1/TNFRSF23 Met30-Ser156
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In Western blots, less than 10% cross-reactivity with recombinant mouse (rm) 4-1BB Ligand, recombinant human (rh) BAFF R, rhDcTRAIL R3, rmFas, rmOPG, and rhTRAIL R4 is observed and no cross-reactivity with rmCD27, rmCD30, rmDR3, rhDR6, rmEDAR, recombinant feline Fas, rhFas, recombinant rat Fas, rmGITR, rmHVEM, rmLymphotoxin beta R, rmNGF R, rmOX40, rmTNF RI, rmTNF RII, rhTRAIL R1, or rhTROY is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Mouse DcTRAILR1 and DcTRAILR2 (decoy TRAIL receptors 1 and 2) proteins are receptors for TRAIL according to ligand-receptor binding assays (Schneider et al. 2001). However, overexpression does not cause NF-kB activation or apoptosis, as would be expected of a TRAIL receptor. These observations led researchers to refer to these receptors as decoys. It is thought that cells that express decoy TRAIL receptor decoys at high levels relative to actual TRAIL receptors may use decoys as protection against the cytotoxic action of TRAIL (reviewed in Bouralexis et al. 2005). Additional analysis of these two murine TRAIL decoy receptors should help faciliate the understanding of the complex biology underlying TRAIL ligand/receptor interactions. DcTRAILR1 is an amino acid protein of 176 amino acids (GenBank no: NP-077252.2). DcTRAILR2 is an amino acid protein of 198 amino acids (GenBank no: AAN87807.1).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Decoy TRAIL receptor 1; MGC123882; MGC123883; TNF receptor family member SOB; TNF receptor homolog 1; Tumor necrosis factor receptor p60 homolog 1; Tumor necrosis factor receptor superfamily member 23
基因别名: Dctrailr1; mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1; Tnfrsf23; TNFRSFH23
UniProt ID: (Mouse) Q9ER63
Entrez Gene ID: (Mouse) 79201
