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Invitrogen
Dectin 2 Monoclonal Antibody (3D1)
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Dectin 2 Antibody (MA5-16250) in IHC (P)
Immunohistochemistry analysis of Dectin 2 in normal human spleen tissue. Samples were incubated with Dectin 2 monoclonal antibody (Product # MA5-16250) using a dilution of 5 µg/mL. Peroxidase-conjugate and DAB chromogen. Human tissue TMA was used for this test.
产品信息
MA5-16250
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Mouse
/ IgG3, kappa
分类
Monoclonal
类型
Antibody
克隆号
3D1
抗原
A blend of two peptides made to amino acids 44-63 and 90-106 of human Dectin-2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Sequence homology: Bovine/Sheep (83%), Mouse (65%), Rat (52%).
靶标信息
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes. It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain. Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells. Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcRg for internalization and to activate NF-kappaB pathway for cytokine production. Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections. Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10; C-type lectin domain family 6 member A; C-type lectin domain family 6, member A; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin 2; dectin-2; Dendritic cell-associated C-type lectin 2
基因别名: CLEC4N; CLEC6A; CLECSF10; DECTIN2
UniProt ID: (Human) Q6EIG7
Entrez Gene ID: (Human) 93978
