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Invitrogen
Defensin alpha-3 Polyclonal Antibody
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Defensin alpha-3 Antibody (PA5-119080) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Defensin alpha-3 in human liver cancer tissue using Defensin alpha-3 Polyclonal Antibody (Product # PA5-119080) (30 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
产品信息
PA5-119080
产品规格
种属反应
Human,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Defensin Alpha 3, Neutrophil Specific. The antigen corresponds to amino acid range 21-94 of the target protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Defensin alpha-1 is part of a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. Defensins are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The Defensin alpha-1 protein is encoded by the DFA1 gene and is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8, and this gene differs from defensin, alpha 3 by only one amino acid. The DFA1 gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms of Defensin alpha-1 have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: defensin 3; defensin 3, neutrophil-specific; defensin precursor; Defensin, alpha 3; defensin, alpha 3, neutrophil-specific; HNP-3; HP-3; Neutrophil defensin 3; neutrophil peptide 3; unnamed protein product
基因别名: DEF3; DEFA3; HNP-3; HNP3; HP-3; HP3
UniProt ID: (Human) P59666
Entrez Gene ID: (Human) 1668
innate immune response in mucosa
defense response
antibacterial humoral response
intracellular estrogen receptor signaling pathway
killing of cells of other organism
defense response to bacterium
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
defense response to virus
membrane disruption in other organism
antimicrobial humoral immune response mediated by antimicrobial peptide
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