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Agrisera
Deg1/chloroplastic DegP-type serine protease 1 Polyclonal Antibody
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产品信息
AS07-246
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant Deg1 of Arabidopsis thaliana, At3g27925, overexpressed in E.coli.
偶联物
形式
Lyophilized
规格
360 µg
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 200 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana, Pisum sativum, Zea mays
靶标信息
Deg1 encodes a soluble tRNA pseudouridine(38/39) synthase that localizes to both the nucleus and cytoplasm and acts on cytoplasmic as well as mitochondrial tRNAs. The protein is a basic ~442 amino acid enzyme that belongs to the TruA/Pus3-like family of stand-alone pseudouridine synthases and contains a conserved catalytic core in which an essential aspartate residue mediates uridine isomerization. Functionally, Deg1 catalyzes formation of pseudouridine at positions 38 and 39 within the tRNA anticodon stem-loop, a conserved modification important for maintaining efficient and accurate translation; loss of Deg1 activity reduces pseudouridylation at these sites, compromises growth particularly at elevated temperature, and has been linked to altered translational recoding (e.g., frameshifting/readthrough) and downstream nuclear phenotypes consistent with translation-dependent effects on genome maintenance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deg1; DegP protease 1; DEGP1; degradation of periplasmic proteins 1
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