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Invitrogen
Demupitamab Recombinant Human Monoclonal Antibody
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产品信息
MA5-59381
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Demupitamab, also referred to as immunoglobulin G1-kappa, is a monoclonal antibody that targets the human epidermal growth factor receptor (EGFR or HER1). The ERBB1 gene, also known as EGFR (Epidermal Growth Factor Receptor), encodes a transmembrane receptor that is a member of the ErbB family of receptor tyrosine kinases (RTKs). This family also includes ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). ERBB1/EGFR is located on chromosome 7p11.2 and consists of 28 exons. The receptor is activated by binding of specific ligands such as EGF and TGF-alpha, which induces conformational changes leading to dimerization, autophosphorylation, and downstream signaling through pathways such as MAPK, PI3K/AKT, and JAK/STAT. These signaling cascades regulate cell proliferation, survival, and differentiation. Aberrant activation of ERBB1/EGFR, often due to mutations, gene amplification, or overexpression, is implicated in various cancers, particularly non-small cell lung cancer (NSCLC), glioblastoma, and colorectal cancer. Targeted therapies, including tyrosine kinase inhibitors (TKIs) and monoclonal antibodies, have been developed to inhibit ERBB1/EGFR signaling, offering clinical benefits in treating EGFR-driven tumors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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