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Invitrogen
Dengue Virus Type 1-4 NS2B (Thailand/16681/1984) Recombinant Rabbit Monoclonal Antibody (HL2513)
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Dengue Virus Type 1-4 NS2B (Thailand/16681/1984) Antibody (MA5-56675) in ICC/IF
Immunocytochemistry analysis of Dengue virus infected cells using Dengue Virus Type 1-4 NS2B (Thailand/16681/1984) (Product # MA5-56675) on ZIKV, CHIKV, DENV 1, DENV2, DENV3, and DENV 4 infected cells slides. Green: Dengue Virus Type 1-4 NS2B diluted at 1:100. Blue: Fluoroshield with DAPI.
产品信息
MA5-56675
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2513
抗原
Full lengh of Dengue virus NS2B protein. (strain Thailand/16681/1984)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
The Dengue Virus Type 1-4 NS2B protein is a non-structural protein that is integral to the replication and maturation of the dengue virus, encompassing all four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). NS2B functions as a crucial cofactor for the NS3 protease, forming a complex that is essential for the cleavage of the viral polyprotein into its constituent proteins. These proteins are necessary for the assembly and replication of new viral particles within the host cell. NS2B is an integral membrane protein that not only aids in the proper folding and activation of the NS3 protease but also plays a role in the viral replication complex formation. Dengue virus is transmitted to humans primarily through the bites of Aedes mosquitoes and can cause dengue fever, characterized by symptoms such as high fever, severe headache, retro-orbital pain, joint and muscle pain, rash, and in severe cases, hemorrhagic manifestations or dengue shock syndrome. Given its pivotal role in the viral life cycle, the NS2B-NS3 protease complex is a significant target for antiviral drug development. Inhibiting this protease activity could potentially prevent viral replication and reduce the severity of the disease. Research into the structure and function of the NS2B protein across all four dengue virus serotypes is essential for developing broad-spectrum antiviral therapies and improving our understanding of dengue virus pathogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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