Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Dengue Virus Type 2/4 NS2B (Thailand/16681/1984) Recombinant Rabbit Monoclonal Antibody (HL2512)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 2
Dengue Virus Type 2/4 NS2B (Thailand/16681/1984) Antibody (MA5-56674) in ICC/IF
Immunocytochemistry analysis of Dengue virus infected cells using Dengue Virus Type 2/4 NS2B (Thailand/16681/1984) (Product # MA5-56674) Recombinant Monoclonal antibody on ZIKV, CHIKV, DENV 1, DENV2, DENV3, and DENV 4 infected cells slides. Green: Dengue Virus Type 2/4 NS2B antibody diluted at 1:100. Blue: Fluoroshield with DAPI.
产品信息
MA5-56674
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2512
抗原
Full lengh of Dengue virus NS2B protein. (strain Thailand/16681/1984)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
The Dengue Virus Type 2/4 NS2B protein is a non-structural protein that plays a critical role in the viral life cycle. NS2B is part of the dengue virus (DENV) protease complex, specifically functioning as a cofactor for the NS3 protease. This complex is essential for the cleavage of the viral polyprotein into individual functional proteins, which are necessary for viral replication and assembly. The non-structural protein 2B (NS2B) is an integral membrane protein and is involved in the proper folding and activation of the NS3 protease, making it a key player in the virus's ability to replicate within the host cell. Dengue virus, which includes four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4), is transmitted to humans by Aedes mosquitoes and causes dengue fever, a disease that can range from mild to severe, with symptoms including high fever, severe headache, pain behind the eyes, joint and muscle pain, rash, and in severe cases, hemorrhagic fever or dengue shock syndrome. The NS2B protein, along with NS3, represents an important target for antiviral drug development, as inhibiting this protease activity can potentially halt viral replication. Understanding the structure and function of the NS2B protein in both DENV-2 and DENV-4 serotypes is crucial for designing effective antiviral therapies and for advancing our knowledge of dengue virus pathogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
